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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2increases phosphorylationEXP 6480464CTDGlucose results in increased phosphorylation of SMAD2 proteinPMID:31838053
Smad2multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]; farrerol inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]; LY2109761 inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]PMID:31838053
Smad2increases phosphorylationISOSMAD2 (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of SMAD2 proteinPMID:21367880
Smad2multiple interactionsISOSMAD2 (Homo sapiens)6480464CTDGlucose results in increased phosphorylation of and affects the localization of SMAD2 protein; isoangustone A inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein]; protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]PMID:17597607 PMID:21367880
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