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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3006
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lhb
Name: luteinizing hormone subunit beta
Acc ID: CHEBI:17489
Term: 3',5'-cyclic AMP
Definition: A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase.
Chemical ID: MESH:D000242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lhbincreases abundanceEXP 6480464CTDLHB protein results in increased abundance of Cyclic AMPPMID:6430271
Lhbincreases chemical synthesisEXP 6480464CTDLHB protein results in increased chemical synthesis of Cyclic AMPPMID:2153673
Lhbmultiple interactionsEXP 6480464CTD5,8,11,14-Eicosatetraynoic Acid inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]; [Flufenamic Acid results in decreased abundance of Cyclic AMP] which results in decreased expression of LHB mRNA; [LHB protein co-treated with Guanylyl Imidodiphosphate] results in increased chemical synthesis of Cyclic AMP; CRH protein inhibits the reaction [[LHB protein co-treated with Guanylyl Imidodiphosphate] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [LHB protein results in increased chemical synthesis of Cyclic AMP]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]; Tetradecanoylphorbol Acetate inhibits the reaction [[LHB protein co-treated with Guanylyl Imidodiphosphate] results in increased chemical synthesis of Cyclic AMP]; Tetradecanoylphorbol Acetate inhibits the reaction [LHB protein results in increased chemical synthesis of Cyclic AMP]PMID:2153673 PMID:6430271 PMID:8404651
Lhbaffects secretionISOLHB (Homo sapiens)6480464CTDLHB protein affects the secretion of Cyclic AMPPMID:23071612
Lhbincreases abundanceISOLHB (Homo sapiens)6480464CTDLHB protein results in increased abundance of Cyclic AMPPMID:33638691
Lhbmultiple interactionsISOLHB (Homo sapiens)6480464CTD[LHB protein affects the secretion of Cyclic AMP] which results in increased secretion of Progesterone; [LHB protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Cyclic AMP; DDT inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]PMID:23071612 PMID:33638691
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