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GENE - TERM ANNOTATION REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: DOID:9970
Term: obesity
Definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Obesity "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepr IAGP 628581RGDcompared to heterozygous controls +/fa 
Lepr IAGP 628910RGDcompared to age-matched lean +/fa rats 
Lepr IAGP 729297RGDDNA:missense mutation:CDS:p.Q269P (rat) 
Lepr IAGP 1600612RGD  
Lepr IAGP 401960103RGDDNA:mutations:cds: : (rat) 
Lepr IAGP 401965413RGDDNA:mutations:cds: : (rat) 
Lepr IAGP 401965414RGDDNA:mutations::cds: : (rat) 
Leprsexual_dimorphismIAGP 7365117RGDcompared to BN 
LeprtreatmentIAGP 401965412RGD  
Lepr IMP 10412038RGD  
Lepr IMP 12910507RGD  
Lepr IMP 12911217RGD  
Leprdisease_progressionIMP 12911217RGD  
Lepr ISOLepr (Mus musculus)5129154RGDmRNA:decreased expression:lung 
Lepr ISOLepr (Mus musculus)10411891RGDprotein:increased expression:hippocampus,astrocyte: 
Leprno_associationISOLEPR (Homo sapiens)10412023RGD  
LeprsusceptibilityISOLEPR (Homo sapiens)5128855RGDDNA:polymorphism:exon:p.Q223R (human) 
LeprtreatmentISOLepr (Mus musculus)10412018RGD  
Lepr ISOLEPR (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:3519326 PMID:17065336 PMID:17229951 PMID:19913045 PMID:20567778 PMID:22276206 PMID:23563609 PMID:24263156 PMID:25222487 PMID:29743445 PMID:30689673 PMID:30993381 PMID:35235096 PMID:35472412
Lepr ISOLEPR (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity disorderPMID:11354636 PMID:11380591 PMID:11443193 PMID:12006639 PMID:17785359 PMID:18490929 PMID:21393862 PMID:21744741 PMID:22331430 PMID:25741868 PMID:26467025 PMID:28492532 PMID:8666155
Lepr ISOLEPR (Homo sapiens)1331525GAD  
Lepr ISSLepr (Mus musculus)13592920MouseDOOMIM:601665 
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