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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Leprincreases expressionEXP 6480464CTDGlucose results in increased expression of LEPR proteinPMID:24399619
Leprmultiple interactionsEXP 6480464CTDnaringin inhibits the reaction [Glucose results in increased expression of LEPR protein]PMID:24399619
Lepraffects abundanceISOLepr (Mus musculus)6480464CTDLEPR affects the abundance of Glucose; LEPR protein affects the abundance of GlucosePMID:16427799 PMID:20567778
Leprdecreases response to substanceISOLepr (Mus musculus)6480464CTDLEPR results in decreased susceptibility to GlucosePMID:20567778
Leprmultiple interactionsISOLepr (Mus musculus)6480464CTDHesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; naringin affects the reaction [LEPR protein affects the abundance of Glucose]PMID:16427799
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