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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Leprmultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LEPR mRNA; [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LEPR mRNAPMID:17602206 PMID:18164116
Leprincreases expressionISOLepr (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of LEPR mRNAPMID:24535843
Leprmultiple interactionsISOLepr (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of LEPR mRNAPMID:24535843
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