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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:16494
Term: lipoic acid
Definition: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepdecreases expressionEXP 6480464CTDThioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP proteinPMID:21351249
Lepdecreases expressionISOLep (Mus musculus)6480464CTDThioctic Acid results in decreased expression of LEP mRNAPMID:21351249
Lepdecreases secretionISOLep (Mus musculus)6480464CTDThioctic Acid results in decreased secretion of LEP proteinPMID:21351249
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