GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lep | multiple interactions | ISO | Lep (Mus musculus) | 6480464 | CTD | [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LEP protein; [Dietary Fats co-treated with Choline deficiency] results in increased expression of LEP protein; [LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SLCO1B2 mRNA; [LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC1 mRNA; [LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC2 mRNA; [LEP gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased abundance of Glucose; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP1A2 protein; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2C29 mRNA; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2C29 protein; [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein; [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of LEP protein; LEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of GPT protein]; LEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]; LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]; PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of LEP protein] | PMID:24384915 PMID:27712037 PMID:28973532 PMID:29246445 | | ||||||||||||||||||||||
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