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RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of KRT8 mRNA

PMID:29097150, PMID:30387366
increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of KRT8 mRNA

PMID:15576828, PMID:17557909, PMID:19400957, PMID:24096037
increases expressionISORGD:7355376480464CTDEthinyl Estradiol results in increased expression of KRT8 mRNA

PMID:17942748, PMID:19400957, PMID:24096037
multiple interactionsISORGD:7355376480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRT8 mRNA

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.