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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of KRT8 protein

PMID:16456883
increases expressionEXP 6480464CTDsodium arsenite results in increased expression of KRT8 protein

PMID:29459688
multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [sodium arsenite results in decreased expression of KRT8 protein], sodium arsenite promotes the reaction [Benzo(a)pyrene results in decreased expression of KRT8 protein]

PMID:16456883
affects expressionISORGD:7355376480464CTDsodium arsenite affects the expression of KRT8 mRNA

PMID:16507464
decreases expressionISORGD:7355366480464CTDsodium arsenite results in decreased expression of KRT8 mRNA

PMID:12634122
increases expressionISORGD:7355366480464CTDsodium arsenite results in increased expression of KRT8 mRNA, sodium arsenite results in increased expression of KRT8 protein

PMID:12016162, PMID:19524636
increases expressionISORGD:7355376480464CTDsodium arsenite results in increased expression of KRT8 mRNA, sodium arsenite results in increased expression of KRT8 protein

PMID:14691202, PMID:15276417, PMID:16507464, PMID:29044176
multiple interactionsISORGD:7355376480464CTD[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRT8 mRNA, [sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of KRT8 protein

PMID:16368122
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.