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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Junb
Name: JunB proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junbdecreases expressionISOJUNB (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of JUNB mRNAPMID:20458559
Junbdecreases expressionISOJunb (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of JUNB mRNAPMID:19410645
Junbincreases expressionISOJUNB (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of JUNB mRNA; Arsenic Trioxide results in increased expression of JUNB proteinPMID:23883479 PMID:25258189
Junbmultiple interactionsISOJUNB (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUNB mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUNB protein]PMID:23883479
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