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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects response to substanceEXP 6480464CTDJUN protein affects the susceptibility to PhenylephrinePMID:11799083
Junincreases activityEXP 6480464CTDPhenylephrine results in increased activity of JUN proteinPMID:15949472
Junincreases expressionEXP 6480464CTDPhenylephrine results in increased expression of JUN; Phenylephrine results in increased expression of JUN mRNA; Phenylephrine results in increased expression of JUN proteinPMID:12169099 PMID:14764439 PMID:19002563 PMID:19225867 PMID:19443575 PMID:7905536
Junincreases phosphorylationEXP 6480464CTDPhenylephrine results in increased phosphorylation of JUN proteinPMID:12169099 PMID:20067472
Junmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; CEP-11004 inhibits the reaction [Phenylephrine results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; JUN gene mutant form inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]; MAPK1 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; MAPK3 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; Phenylephrine inhibits the reaction [MAPK7 protein results in increased expression of JUN protein]; Phenylephrine promotes the reaction [JUN protein binds to FOS protein]; pyrazolanthrone inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; RPS6KA5 protein promotes the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]PMID:11799083 PMID:12574153 PMID:14764439 PMID:19002563 PMID:20067472
Junincreases expressionISOJun (Mus musculus)6480464CTDPhenylephrine results in increased expression of JUN mRNAPMID:16690042
Junmultiple interactionsISOJun (Mus musculus)6480464CTD[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of JUN mRNA]PMID:10710348
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