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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsEXP 6480464CTD[Clofibrate co-treated with PPARA protein] inhibits the reaction [JUN protein results in increased expression of GSTP1 mRNA]; JUN protein inhibits the reaction [Clofibrate results in increased activity of PPARA protein]PMID:7585603
Junincreases expressionISOJun (Mus musculus)6480464CTDClofibrate analog results in increased expression of JUN mRNA; Clofibrate results in increased expression of JUN mRNA; Clofibrate results in increased expression of JUN proteinPMID:20025956 PMID:23811191 PMID:8764118
Junmultiple interactionsISOJun (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of JUN mRNA; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of JUN mRNA]PMID:17585979
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDClofibrate inhibits the reaction [Glucose results in increased expression of JUN protein]PMID:16600694
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