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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects expressionISOJUN (Homo sapiens)6480464CTDarsenite affects the expression of JUN mRNAPMID:22959463
Junincreases expressionISOJUN (Homo sapiens)6480464CTDarsenite results in increased expression of JUN mRNA; arsenite results in increased expression of JUN proteinPMID:16085347 PMID:22260869
Junincreases phosphorylationISOJun (Mus musculus)6480464CTDarsenite results in increased phosphorylation of JUN proteinPMID:19059425
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDarsenite results in increased phosphorylation of JUN proteinPMID:15037631 PMID:23469214
Junmultiple interactionsISOJun (Mus musculus)6480464CTDJUN mutant form inhibits the reaction [arsenite results in increased expression of CCND1 mRNA]PMID:19059425
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [arsenite results in increased expression of JUN protein]; caffeic acid phenethyl ester inhibits the reaction [arsenite results in increased expression of JUN mRNA]PMID:16085347 PMID:22260869
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