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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases expressionEXP 6480464CTDRotenone results in increased expression of JUN mRNAPMID:28374803
Junincreases phosphorylationEXP 6480464CTDRotenone results in increased phosphorylation of JUN proteinPMID:27535828 PMID:30472438
Junmultiple interactionsEXP 6480464CTD1-(1-acetyl-piperidine-4-yl)-3-adamantan-1-yl-urea inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]PMID:27535828 PMID:30472438
Junincreases expressionISOJUN (Homo sapiens)6480464CTDRotenone results in increased expression of JUN protein; Rotenone results in increased expression of JUN protein modified formPMID:32368861
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDRotenone results in increased phosphorylation of JUN proteinPMID:17324951 PMID:18242171 PMID:20594614
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDkaempferol inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; PSME4 protein promotes the reaction [Rotenone results in increased expression of JUN protein]; ropinirole inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]; Rotenone results in increased phosphorylation of and results in increased activity of JUN proteinPMID:14976342 PMID:18242171 PMID:20594614 PMID:32368861
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