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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2933
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr1affects expressionISOITPR1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of ITPR1 mRNAPMID:21714911
Itpr1affects methylationISOITPR1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ITPR1 intronPMID:30157460
Itpr1decreases expressionISOItpr1 (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of ITPR1 mRNAPMID:32553695
Itpr1decreases expressionISOITPR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ITPR1 mRNAPMID:20064835 PMID:20106945 PMID:21632981
Itpr1decreases methylationISOItpr1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of ITPR1 intronPMID:27901495
Itpr1increases expressionISOItpr1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ITPR1 mRNAPMID:20127859 PMID:22228805
Itpr1increases expressionISOITPR1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ITPR1 mRNAPMID:22316170 PMID:26238291
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