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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins2
Name: insulin 2
Acc ID: CHEBI:73458
Term: NS-398
Definition: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Chemical ID: MESH:C080955
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2increases secretionISOINS (Homo sapiens)6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased secretion of INS proteinPMID:17192482
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Arachidonic Acid results in increased secretion of INS protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Glucose results in increased secretion of INS protein]PMID:17192482
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