GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | multiple interactions | EXP | | 6480464 | CTD | fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; fulvestrant inhibits the reaction [resveratrol results in decreased expression of IL6 protein] | PMID:18277952 PMID:21192278 PMID:25738436 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | fulvestrant results in increased expression of IL6 mRNA | PMID:16298037 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | Fulvestrant inhibits the reaction [bazedoxifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased secretion of IL6 protein]; Fulvestrant inhibits the reaction [bisphenol F results in increased secretion of IL6 protein]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; Fulvestrant inhibits the reaction [Ospemifene inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] | PMID:19533603 PMID:21501669 PMID:23943137 PMID:24771768 PMID:25047101 PMID:28500084 PMID:34147605 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | [bisphenol S co-treated with Fulvestrant] results in increased methylation of IL6 gene; Fulvestrant inhibits the reaction [[bisphenol A co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 protein]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [CREBBP protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOA2 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOA3 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NCOR2 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [NMNAT1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [RCOR1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [RELA protein modified form binds to IL6 promoter]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]]; Fulvestrant inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased secretion of IL6 protein]] | PMID:24771768 PMID:25128825 PMID:31601247 | | ||||||||||||||||||||||
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