GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of IL6 protein | PMID:34999049 | Il6 | multiple interactions | EXP | | 6480464 | CTD | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[TNF protein co-treated with Benzo(a)pyrene] results in increased expression of IL6 protein]; [IL27 protein co-treated with IFNL3 protein] inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]; Benzo(a)pyrene promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] | PMID:21745554 PMID:34999049 | Il6 | affects methylation | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of IL6 5' UTR | PMID:27901495 | Il6 | increases activity | ISO | Il6 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased activity of IL6 protein | PMID:31702096 | Il6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of IL6 mRNA; Benzo(a)pyrene results in increased expression of IL6 protein | PMID:30165701 PMID:32061149 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of IL6 mRNA | PMID:16002475 PMID:25433334 PMID:28351761 PMID:29787794 PMID:31515600 PMID:32234424 | Il6 | increases methylation | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of IL6 promoter | PMID:27901495 | Il6 | increases secretion | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased secretion of IL6 protein | PMID:16002475 PMID:22404339 PMID:29787794 PMID:31748929 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of IL6 mRNA; Benzo(a)pyrene inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Benzo(a)pyrene inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 mRNA] | PMID:25820237 PMID:30165701 PMID:32061149 PMID:34998820 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | [Benzo(a)pyrene co-treated with TNF protein] results in increased expression of IL6 mRNA; [IL6 protein co-treated with Benzo(a)pyrene] results in decreased expression of MIR27B mRNA; AHR protein affects the reaction [Benzo(a)pyrene results in increased secretion of IL6 protein]; IL6 protein affects the reaction [[AHR protein affects the susceptibility to Benzo(a)pyrene] which affects the phosphorylation of STAT3 protein]; IL6 protein affects the reaction [Benzo(a)pyrene results in increased expression of SOCS3 protein]; IL6 protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; nifuroxazide inhibits the reaction [Benzo(a)pyrene results in increased secretion of IL6 protein]; SOCS3 protein affects the reaction [Benzo(a)pyrene results in increased secretion of IL6 protein] | PMID:23396138 PMID:31515600 PMID:31748929 | | ||||||||||||||||||||||
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