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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:16827
Term: corticosterone
Definition: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Chemical ID: MESH:D003345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTDCorticosterone inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]PMID:28782715
Il6decreases expressionISOIl6 (Mus musculus)6480464CTDCorticosterone results in decreased expression of IL6 mRNAPMID:28500787 PMID:29846716
Il6increases expressionISOIl6 (Mus musculus)6480464CTDCorticosterone results in increased expression of IL6 mRNAPMID:30993381
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTD[Corticosterone co-treated with Physostigmine] results in decreased expression of IL6 mRNA; [Pyridostigmine Bromide co-treated with Corticosterone] results in decreased expression of IL6 mRNA; Corticosterone inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of IL6 mRNA]; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Isoflurophate inhibits the reaction [Corticosterone results in decreased expression of IL6 mRNA]; O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [Corticosterone results in decreased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]PMID:28500787 PMID:29846716 PMID:30993381
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