GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | decreases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | daidzein results in decreased expression of IL6 mRNA | PMID:27576059 | Il6 | decreases secretion | ISO | IL6 (Homo sapiens) | 6480464 | CTD | daidzein results in decreased secretion of IL6 protein | PMID:27576059 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | [Genistein co-treated with daidzein] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein]; daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; daidzein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] | PMID:21945492 PMID:21972936 PMID:22981962 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | daidzein inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; ESR1 protein affects the reaction [daidzein results in decreased expression of IL6 mRNA]; ESR1 protein affects the reaction [daidzein results in decreased secretion of IL6 protein] | PMID:17266178 PMID:27576059 | | ||||||||||||||||||||||
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