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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDToluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA, Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein

PMID:11758997, PMID:15950818, PMID:19050374, PMID:19075512, PMID:23333628
multiple interactionsEXP 6480464CTDChlorpheniramine inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], epinastine inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], Olopatadine Hydrochloride inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], Quercetin inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], sho-seiryu-to inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA]

PMID:19050374, PMID:19075512, PMID:23333628
affects secretionISORGD:107966480464CTDToluene 2, 4-Diisocyanate affects the secretion of IL4 protein

PMID:19150644
increases expressionISORGD:107966480464CTDToluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA, Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein

PMID:10637130, PMID:11243917, PMID:11467998, PMID:11708898, PMID:12356572, PMID:12789230, PMID:12884401, PMID:12956900, PMID:15590890, PMID:16210060, PMID:16271432, PMID:16940033, PMID:17014439, PMID:17015710, PMID:17257216, PMID:17641053, PMID:17980417, PMID:18652873, PMID:19042193, PMID:19422874, PMID:19428947, PMID:20219652, PMID:22381623, PMID:28826779, PMID:30017638, PMID:30261222
increases expressionISORGD:7363066480464CTDToluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA

PMID:20371970
increases secretionISORGD:107966480464CTDToluene 2, 4-Diisocyanate results in increased secretion of IL4 protein

PMID:17693426, PMID:25929181, PMID:28329851, PMID:30517707
increases secretionISORGD:7363066480464CTDToluene 2, 4-Diisocyanate results in increased secretion of IL4 protein

PMID:20371970
multiple interactionsISORGD:107966480464CTD2-(1, 3-dimethyl-2, 6-dioxo-1, 2, 3, 6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased secretion of IL4 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased secretion of IL4 protein], 4, 4', 4''-(4-propyl-((1)H)-pyrazole-1, 3, 5-triyl) tris-phenol promotes the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], [Toluene 2, 4-Diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein, AG 1879 inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], AWD 12-281 inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], BAY 11-7085 inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], bisphenol A promotes the reaction [Toluene 2, 4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein], CD4 protein affects the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], Cilomilast inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], diflorasone inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], Estradiol promotes the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], FPS-ZM1 inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], GSK2193874 inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased secretion of IL4 protein], ICAM1 protein affects the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], IL1A protein affects the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], IL1B protein affects the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], Methoxychlor promotes the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], Pioglitazone inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], PPARG protein affects the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], Rosiglitazone inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 protein], TNF protein affects the reaction [Toluene 2, 4-Diisocyanate results in increased expression of IL4 mRNA], Toluene 2, 4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein, TSLP protein alternative form inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased secretion of IL4 protein]

PMID:12356572, PMID:12789230, PMID:12956900, PMID:15588918, PMID:15590890, PMID:16210060, PMID:17014439, PMID:17015710, PMID:25929181, PMID:28329851, PMID:29846729, PMID:30017638, PMID:30261222, PMID:30517707
multiple interactionsISORGD:7363066480464CTD1, 2-bis(2-aminophenoxy)ethane-N, N, N', N'-tetraacetic acid inhibits the reaction [Toluene 2, 4-Diisocyanate results in increased secretion of IL4 protein]

PMID:20371970
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.