GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il4 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of IL4 mRNA | PMID:25181051 | Il4 | multiple interactions | EXP | | 6480464 | CTD | [Phytochemicals co-treated with bisphenol A] results in decreased expression of IL4 | PMID:20136622 | Il4 | affects expression | ISO | Il4 (Mus musculus) | 6480464 | CTD | bisphenol A affects the expression of IL4 mRNA | PMID:29248573 | Il4 | decreases expression | ISO | Il4 (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased expression of IL4 mRNA; bisphenol A results in decreased expression of IL4 protein | PMID:12510852 PMID:29161229 PMID:32156529 | Il4 | decreases expression | ISO | IL4 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of IL4 mRNA | PMID:31714645 | Il4 | decreases methylation | ISO | IL4 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased methylation of IL4 gene | PMID:31601247 | Il4 | decreases secretion | ISO | IL4 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased secretion of IL4 protein | PMID:31714645 | Il4 | increases expression | ISO | Il4 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of IL4 mRNA; bisphenol A results in increased expression of IL4 protein | PMID:12709020 PMID:20553123 PMID:29737898 PMID:35278557 | Il4 | increases expression | ISO | IL4 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of IL4 mRNA | PMID:19415476 | Il4 | increases secretion | ISO | Il4 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased secretion of IL4 protein | PMID:12711627 | Il4 | multiple interactions | ISO | Il4 (Mus musculus) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; [bisphenol A affects the susceptibility to Ovalbumin] which results in increased expression of IL4 protein; [bisphenol A co-treated with Ovalbumin] results in increased expression of IL4 mRNA; [bisphenol A results in increased susceptibility to Ovalbumin] which results in increased expression of IL4 mRNA; [Ovalbumin co-treated with bisphenol A] results in increased expression of and results in increased secretion of IL4 protein; [Ovalbumin co-treated with bisphenol A] results in increased secretion of IL4 protein; bisphenol A inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone inhibits the reaction [Ovalbumin results in increased expression of IL4 protein]]; bisphenol A promotes the reaction [[[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC3 protein binds to IL4 promoter]] which results in increased expression of IL4 mRNA]; bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]; bisphenol A promotes the reaction [Ovalbumin results in increased expression of IL4 protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein]; Nitrendipine inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Phytochemicals inhibits the reaction [bisphenol A results in increased expression of IL4 mRNA]; Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Thapsigargin inhibits the reaction [bisphenol A results in increased expression of IL4 protein] | PMID:12709020 PMID:20553123 PMID:29737898 PMID:29846729 PMID:31788436 PMID:32012983 PMID:32964057 PMID:35533451 | Il4 | multiple interactions | ISO | IL4 (Homo sapiens) | 6480464 | CTD | Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in increased expression of IL4 mRNA]; NFATC2 protein affects the reaction [bisphenol A results in decreased expression of IL4 mRNA] | PMID:19415476 PMID:31714645 | |
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