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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4decreases expression ISOIl4 (Mus musculus)39939037RGDtetrachloromethane decreases expression of Il4 protein in serum 
Il4increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of IL4 mRNAPMID:14567445
Il4multiple interactionsEXP 6480464CTDEdaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA]PMID:14567445
Il4decreases expressionISOIl4 (Mus musculus)6480464CTDCarbon Tetrachloride results in decreased expression of IL4 mRNAPMID:25827057
Il4increases expressionISOIl4 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of IL4 mRNA; Carbon Tetrachloride results in increased expression of IL4 proteinPMID:17038628 PMID:17412915 PMID:18279442 PMID:27865854
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTDGlatiramer Acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]; IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]; obeticholic acid promotes the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA]; PLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]; PLAU protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]; PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]PMID:17038628 PMID:17412915 PMID:18279442 PMID:27865854
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