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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of IL4 mRNA

PMID:14567445
multiple interactionsEXP 6480464CTDEdaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA]

PMID:14567445
decreases expressionISORGD:107966480464CTDCarbon Tetrachloride results in decreased expression of IL4 mRNA

PMID:25827057
increases expressionISORGD:107966480464CTDCarbon Tetrachloride results in increased expression of IL4 mRNA, Carbon Tetrachloride results in increased expression of IL4 protein

PMID:17038628, PMID:17412915, PMID:18279442, PMID:27865854
multiple interactionsISORGD:107966480464CTDGlatiramer Acetate inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 protein], IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein], obeticholic acid promotes the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA], PLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein], PLAU protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein], PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]

PMID:17038628, PMID:17412915, PMID:18279442, PMID:27865854
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.