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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107966480464CTD[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased abundance of Glutathione

PMID:22107450
multiple interactionsISORGD:7363066480464CTD[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein, Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species], Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]

PMID:18214930, PMID:27634759
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.