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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2895
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il2ra
Name: interleukin 2 receptor subunit alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il2raincreases expressionISOIL2RA (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IL2RA mRNAPMID:35811015
Il2raincreases expressionISOIl2ra (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of IL2RA mRNAPMID:22169119
Il2ramultiple interactionsISOIL2RA (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IL2RA mRNAPMID:35811015
Il2ramultiple interactionsISOIl2ra (Mus musculus)6480464CTD[Eicosapentaenoic Acid co-treated with Lipopolysaccharides] results in increased expression of IL2RA mRNA; Eicosapentaenoic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]; procyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]PMID:22169119
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