Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IL1B mRNAPMID:26808241
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL1B proteinPMID:37357614
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL1B mRNAPMID:37357614
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [Cadmium results in increased expression of IL1B protein]; Cadmium promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL1B protein]PMID:37357614
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[Cadmium co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of IL1B mRNA; GSK872 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL1B mRNA]; GSK872 inhibits the reaction [[Cadmium co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of IL1B mRNA]PMID:37357614
Go Back to source page   Continue to Ontology report