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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1baffects expressionEXP 6480464CTDArsenic Trioxide affects the expression of IL1B mRNA; Arsenic Trioxide affects the expression of IL1B proteinPMID:31734849 PMID:32096187
Il1bincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of IL1B mRNA; Arsenic Trioxide results in increased expression of IL1B proteinPMID:29130132 PMID:30368975 PMID:30660605 PMID:32919218
Il1bmultiple interactionsEXP 6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL1B protein]; [Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL1B protein]; Arsenic Trioxide results in increased expression of and results in increased secretion of IL1B protein; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]; Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; NEAT1 mRNA affects the reaction [Arsenic Trioxide affects the expression of IL1B mRNA]; NEAT1 mRNA affects the reaction [Arsenic Trioxide affects the expression of IL1B protein]; polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B mRNA]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of IL1B protein]; Taurine inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]PMID:27174766 PMID:29130132 PMID:30368975 PMID:30660605 PMID:32096187 PMID:32919218
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of IL1B; Arsenic Trioxide results in decreased expression of IL1B mRNAPMID:20693187 PMID:27461142 PMID:35676786
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of IL1B mRNAPMID:22535156
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of IL1B mRNA; Arsenic Trioxide results in increased expression of IL1B proteinPMID:30237538 PMID:33603344 PMID:33846815 PMID:35317438
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of IL1B mRNA; Arsenic Trioxide results in increased expression of IL1B proteinPMID:20458559 PMID:31734849 PMID:32240679 PMID:35226250
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDArsenic Trioxide results in increased secretion of IL1B proteinPMID:35226250
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDArsenic Trioxide results in increased secretion of IL1B proteinPMID:35226250
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B mRNA]; 18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Arsenic Trioxide results in decreased expression of IL1B mRNA]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in decreased expression of IL1B mRNA]; [Arsenic Trioxide results in increased abundance of arsenite] which results in increased expression of IL1B protein; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B protein]; Arsenic Trioxide inhibits the reaction [anthrax toxin results in increased secretion of and results in increased cleavage of IL1B protein]; Arsenic Trioxide inhibits the reaction [Nigericin results in increased cleavage of IL1B protein]; Arsenic Trioxide promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; ATF4 protein affects the reaction [Arsenic Trioxide results in decreased expression of IL1B mRNA]; Plant Extracts inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic Trioxide] which results in increased expression of IL1B protein]; Quin2 inhibits the reaction [Arsenic Trioxide results in decreased expression of IL1B mRNA]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]PMID:20339114 PMID:23430110 PMID:24337744 PMID:27461142 PMID:30237538 PMID:32226249 PMID:33603344 PMID:33846815 PMID:35317438 PMID:36791901
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; [acetyl-11-ketoboswellic acid co-treated with Arsenic Trioxide] results in decreased secretion of IL1B protein; [Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL1B protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of IL1B mRNA]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased secretion of IL1B protein]; AS3MT mRNA promotes the reaction [Arsenic Trioxide results in increased expression of IL1B protein]; CA 074 methyl ester inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; IGF2BP2 protein promotes the reaction [Arsenic Trioxide results in increased secretion of IL1B protein]; METTL14 protein promotes the reaction [Arsenic Trioxide results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Taurine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]PMID:21078271 PMID:23253724 PMID:26892147 PMID:30237538 PMID:35226250
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