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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDcarvedilol results in decreased expression of IL1B mRNA; carvedilol results in decreased expression of IL1B proteinPMID:16310260 PMID:20017808
Il1bmultiple interactionsEXP 6480464CTDCarvedilol inhibits the reaction [Arginine results in increased expression of IL1B protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL1B mRNA]PMID:10722803 PMID:32569593
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDcarvedilol results in decreased expression of IL1B mRNAPMID:15921778
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDcarvedilol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]PMID:14684360
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