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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:29623
Term: manumycin A
Definition: A polyketide with formula C31H38N2O7 initially isolated from Streptomyces parvulus as a result of a random screening program for farnesyl transferase (FTase) inhibitors. It is a natural product that exhibits anticancer and antibiotic properties.
Chemical ID: MESH:C054474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases response to substanceISOIL1B (Homo sapiens)6480464CTDmanumycin results in decreased susceptibility to IL1B proteinPMID:21211511
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDgeraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]PMID:21430599
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDmanumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]PMID:21211511
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