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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:17883
Term: hydrogen chloride
Definition: A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.
Chemical ID: MESH:D006851
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDHydrochloric Acid results in increased expression of IL1B proteinPMID:15309881
Il1bmultiple interactionsEXP 6480464CTD[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B proteinPMID:15309881
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDHydrochloric Acid results in increased expression of IL1B mRNA; Hydrochloric Acid results in increased expression of IL1B proteinPMID:31900028
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL1B mRNA]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]PMID:25478868 PMID:31900028
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