GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases expression | EXP | | 6480464 | CTD | Indomethacin results in increased expression of IL1B mRNA; Indomethacin results in increased expression of IL1B protein | PMID:11950807 PMID:16133968 PMID:23892052 PMID:25051504 PMID:27645307 PMID:29027214 PMID:30580614 PMID:37676835 | Il1b | increases secretion | EXP | | 6480464 | CTD | Indomethacin results in increased secretion of IL1B protein | PMID:21451212 | Il1b | multiple interactions | EXP | | 6480464 | CTD | [morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B mRNA]; aliskiren inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; cobaltiprotoporphyrin inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Famotidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Gallic Acid analog inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Indomethacin inhibits the reaction [Carrageenan results in increased expression of IL1B mRNA]; Indomethacin inhibits the reaction [Carrageenan results in increased expression of IL1B protein]; Indomethacin inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]; Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Indomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL1B protein results in increased secretion of CRH protein]; Indomethacin promotes the reaction [Acetic Acid results in increased expression of IL1B protein]; Indomethacin promotes the reaction [morin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]]; morin promotes the reaction [Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]]; paeonol inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Theophylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]; TNF protein affects the reaction [Indomethacin results in increased expression of IL1B protein]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of IL1B mRNA] | PMID:11286988 PMID:11376495 PMID:11852909 PMID:16133968 PMID:21983654 PMID:23892052 PMID:25698669 PMID:27645307 PMID:30580614 PMID:34789018 | Il1b | decreases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Indomethacin results in decreased secretion of IL1B protein | PMID:10388637 PMID:10393680 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Indomethacin results in increased expression of IL1B protein | PMID:17329845 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Indomethacin results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Indomethacin results in increased expression of IL1B mRNA | PMID:12517972 PMID:29027214 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Indomethacin results in increased secretion of IL1B protein | PMID:10772282 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [Indomethacin co-treated with Medroxyprogesterone Acetate] results in decreased secretion of IL1B protein; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein]; Indomethacin inhibits the reaction [Carrageenan results in increased secretion of IL1B protein]; Indomethacin inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Indomethacin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; oren gedoku to inhibits the reaction [Indomethacin results in increased expression of IL1B protein] | PMID:16537180 PMID:17329845 PMID:18799549 PMID:29499192 PMID:38705399 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of IL1B mRNA; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2]; Indomethacin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]; Indomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Indomethacin inhibits the reaction [IL1B results in increased activity of EDNRB]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; Indomethacin promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Indomethacin promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] | PMID:10772282 PMID:12126971 PMID:12512699 PMID:12517972 PMID:12743569 PMID:15705740 PMID:16529823 PMID:28628672 PMID:8971655 | | ||||||||||||||||||||||
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