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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:42567
Term: fisetin
Definition: A 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3' and 4'.
Chemical ID: MESH:C017875
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsEXP 6480464CTDfisetin inhibits the reaction [IL1B protein results in decreased expression of ACAN protein]; fisetin inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; fisetin inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; fisetin inhibits the reaction [IL1B protein results in decreased expression of SIRT6 protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of ARPC5 protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of BAX protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of CDKN1A protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of H2AX protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; fisetin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]PMID:38278314
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDfisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein]PMID:18958421
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