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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:38663
Term: ethion
Definition: An organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7).
Chemical ID: MESH:C100038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDethion results in increased expression of IL1B mRNAPMID:30225615
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[ethion co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; Lipopolysaccharides promotes the reaction [ethion results in increased expression of IL1B mRNA]PMID:30225615
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