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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:36904
Term: elemental selenium
Definition: null
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsEXP 6480464CTDSelenium inhibits the reaction [Acrylamide results in increased expression of IL1B protein]PMID:37987225
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDSelenium deficiency results in increased expression of IL1B mRNAPMID:25187657
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDSelenium results in increased expression of IL1B mRNAPMID:17293063
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Selenium co-treated with Lipopolysaccharides co-treated with IL4 protein] results in decreased expression of IL1B mRNA; Selenium inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]PMID:17630198 PMID:21775527
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IL1B mRNA; Selenium affects the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Selenium inhibits the reaction [IL1B protein results in increased abundance of Hydrogen Peroxide]; Selenium promotes the reaction [T-2 Toxin results in increased expression of IL1B protein]PMID:10802230 PMID:18196609 PMID:21481475
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