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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDresveratrol results in decreased expression of IL1B mRNA; resveratrol results in decreased expression of IL1B proteinPMID:19228061 PMID:20036306 PMID:20050970 PMID:21111721 PMID:21439372 PMID:22246136 PMID:24436987 PMID:24513509 PMID:25833014 PMID:26936125 PMID:27093858
Il1bmultiple interactionsEXP 6480464CTD[Fish Oils co-treated with Resveratrol] inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; [Resveratrol co-treated with Streptozocin] results in increased expression of IL1B mRNA; Resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK1 protein modified form]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK3 protein modified form]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK8 protein modified form]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK9 protein modified form]; Resveratrol inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Ammonia results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [chromium hexavalent ion results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Dimethylnitrosamine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Ethanol results in increased expression of IL1B]; Resveratrol inhibits the reaction [Fenitrothion results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Ifosfamide results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Methotrexate results in increased expression of IL1B]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Pilocarpine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Rotenone results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL1B mRNA]; Resveratrol promotes the reaction [Acetic Acid results in increased expression of IL1B protein]PMID:11376495 PMID:15734790 PMID:15971681 PMID:17035056 PMID:17481685 PMID:18424637 PMID:20307516 PMID:20422370 PMID:21439372 PMID:22713680 PMID:23211629 PMID:23284918 PMID:23422878 PMID:23551926 PMID:24234420 PMID:25833014 PMID:25905778 PMID:26055348 PMID:26283207 PMID:26464617 PMID:26517535 PMID:27016191 PMID:27064547 PMID:27093858 PMID:33587916 PMID:33733559 PMID:34302886 PMID:34968465 PMID:35024197 PMID:37009719
Il1bdecreases activityISOIL1B (Homo sapiens)6480464CTDresveratrol results in decreased activity of IL1B proteinPMID:15180920 PMID:26526931
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDresveratrol results in decreased expression of IL1B mRNA; resveratrol results in decreased expression of IL1B proteinPMID:18549505 PMID:21807089
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDResveratrol results in decreased expression of IL1B mRNA; Resveratrol results in decreased expression of IL1B proteinPMID:12689943 PMID:20816778 PMID:22933405 PMID:23224687 PMID:31883986
Il1bdecreases response to substanceISOIL1B (Homo sapiens)6480464CTDIL1B protein results in decreased susceptibility to resveratrol; resveratrol results in decreased susceptibility to IL1B proteinPMID:12689943 PMID:18759268 PMID:21211511 PMID:9974427
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDresveratrol analog results in increased expression of IL1B mRNAPMID:15652768
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDresveratrol results in increased secretion of IL1B proteinPMID:17690738
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDresveratrol analog results in increased secretion of IL1B protein; resveratrol results in increased secretion of IL1B proteinPMID:15135313 PMID:26243699
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Hyaluronic Acid co-treated with Resveratrol] results in decreased expression of IL1B mRNA; [Resveratrol co-treated with beta-1,3-glucan] results in increased secretion of IL1B protein; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; IL10 protein affects the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Resveratrol analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK1 protein modified form]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK3 protein modified form]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Aluminum Chloride results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Arginine results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased secretion of IL1B protein]]; Resveratrol inhibits the reaction [C5 protein results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [TNF protein results in increased expression of IL1B protein]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; tin protoporphyrin IX inhibits the reaction [Resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]PMID:17690738 PMID:18549505 PMID:19284563 PMID:19346296 PMID:19689081 PMID:19940103 PMID:20132809 PMID:20712904 PMID:21284090 PMID:22069489 PMID:22118570 PMID:22363816 PMID:22698256 PMID:22952890 PMID:23593274 PMID:23595953 PMID:23791078 PMID:23973301 PMID:24041027 PMID:24756886 PMID:25576658 PMID:26498332 PMID:27093858 PMID:29197120 PMID:30165701 PMID:33239236 PMID:34391968 PMID:34423886 PMID:34614429 PMID:35156769 PMID:38437956
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]; [Plant Extracts co-treated with Resveratrol] results in decreased expression of IL1B mRNA; [Resveratrol co-treated with nano-diamino-tetrac] results in decreased expression of IL1B mRNA; [Resveratrol co-treated with nano-diamino-tetrac] results in decreased expression of IL1B protein; [Resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of IL1B mRNA]; [Resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of IL1B mRNA]; [Resveratrol co-treated with TLR5 protein] results in increased secretion of IL1B protein; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; KHSRP protein promotes the reaction [Resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]]; KHSRP protein promotes the reaction [Resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]]; KHSRP protein promotes the reaction [Resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of TNF mRNA]]; Pertussis Toxin inhibits the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]]; Pertussis Toxin inhibits the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]]; Resveratrol analog inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of and results in increased secretion of CRP protein]; Resveratrol analog inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of CRP mRNA]; Resveratrol analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of and results in increased secretion of CRP protein]; Resveratrol inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of CRP mRNA]; Resveratrol inhibits the reaction [[IL1B protein co-treated with Oligomycins] affects the localization of RELA protein]; Resveratrol inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased expression of CXCL8 protein]; Resveratrol inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased expression of PTGS2 protein]; Resveratrol inhibits the reaction [[IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Oligomycins co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Resveratrol inhibits the reaction [ALB protein modified form results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [C5 protein results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]]; Resveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]]; Resveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SOX9 mRNA]]; Resveratrol inhibits the reaction [IL1B protein results in decreased expression of ADIPOQ mRNA]; Resveratrol inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; Resveratrol inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of Leukotriene B4]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of Prostaglandin D2]; Resveratrol inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Resveratrol inhibits the reaction [IL1B protein results in increased activity of and results in increased expression of F3 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased activity of CASP3 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased activity of F3 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased activity of PAPPA protein]; Resveratrol inhibits the reaction [IL1B protein results in increased cleavage of PARP1 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased degradation of IGFBP4 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of F3 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of PAPPA protein]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of SERPINE1 mRNA]; Resveratrol inhibits the reaction [IL1B protein results in increased expression of TP53 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of Reactive Oxygen Species]; Resveratrol inhibits the reaction [Linoleic Acids, Conjugated results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Resveratrol promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Resveratrol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]]; Tamoxifen promotes the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]]PMID:10496962 PMID:12689943 PMID:12871381 PMID:15135313 PMID:15180920 PMID:16338976 PMID:17191021 PMID:17388968 PMID:17404069 PMID:17959154 PMID:18377686 PMID:18759268 PMID:18776171 PMID:19284563 PMID:19346296 PMID:19751497 PMID:20426787 PMID:20531350 PMID:21211511 PMID:21289251 PMID:22549761 PMID:23199342 PMID:23557933 PMID:23936610 PMID:24035785 PMID:24149798 PMID:24609059 PMID:24707119 PMID:24781252 PMID:25352548 PMID:26335192 PMID:26526931 PMID:29781141 PMID:31883986 PMID:31943712 PMID:38437956 PMID:9974427
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