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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:15882
Term: phenol
Definition: An organic hydroxy compound that consists of benzene bearing a single hydroxy substituent. The parent of the class of phenols.
Chemical ID: MESH:D019800
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDPhenol results in decreased expression of IL1BPMID:12160195
Il1bmultiple interactionsEXP 6480464CTDtempol inhibits the reaction [Phenol results in decreased expression of IL1B mRNA]PMID:16785328
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDPhenol results in increased expression of IL1B mRNAPMID:8006454
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDPhenol results in increased secretion of IL1B proteinPMID:17922553
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDGlutathione deficiency promotes the reaction [Phenol results in increased secretion of IL1B protein]PMID:17922553
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