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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:144984
Term: NSC 23766
Definition: An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).
Chemical ID: MESH:C487513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDNSC 23766 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]PMID:21511011 PMID:31018152
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDNSC 23766 inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; NSC 23766 inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]PMID:31018152
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