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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1a
Name: interleukin 1 alpha
Acc ID: CHEBI:8426
Term: probenecid
Definition: A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Chemical ID: MESH:D011339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1amultiple interactionsISOIl1a (Mus musculus)6480464CTD1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNAPMID:25406165
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