GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1a | affects activity | EXP | | 6480464 | CTD | Tretinoin affects the activity of IL1A protein | PMID:16847438 | Il1a | increases expression | ISO | IL1A (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased expression of IL1A mRNA | PMID:33167477 | Il1a | multiple interactions | ISO | Il1a (Mus musculus) | 6480464 | CTD | Tretinoin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] | PMID:8435107 | Il1a | multiple interactions | ISO | IL1A (Homo sapiens) | 6480464 | CTD | [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Tretinoin; Tretinoin inhibits the reaction [IL1A protein results in increased expression of IVL mRNA]; Tretinoin inhibits the reaction [IL1A protein results in increased expression of S100A8 mRNA]; Tretinoin inhibits the reaction [IL1A protein results in increased expression of S100A9 mRNA] | PMID:17214633 PMID:19362101 | | ||||||||||||||||||||||
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