GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il18 | increases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased expression of IL18 mRNA; Lipopolysaccharides results in increased expression of IL18 protein | PMID:21882482 PMID:28693884 PMID:33727093 PMID:34464015 PMID:37148149 | Il18 | multiple interactions | EXP | | 6480464 | CTD | [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein; [Particulate Matter co-treated with Lipopolysaccharides] results in increased expression of IL18 protein; FBXO3 protein inhibits the reaction [MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]]; FBXO3 protein promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]; gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]; MIR219A1 mRNA inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein] | PMID:35285579 PMID:35962723 PMID:37148149 | Il18 | affects expression | ISO | Il18 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides affects the expression of IL18 protein | PMID:21055422 | Il18 | increases expression | ISO | IL18 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of IL18 mRNA; Lipopolysaccharides results in increased expression of IL18 protein | PMID:16100009 PMID:17399992 PMID:21147091 PMID:25448682 PMID:28964808 PMID:35953652 PMID:36055550 | Il18 | increases expression | ISO | Il18 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of IL18 mRNA; Lipopolysaccharides results in increased expression of IL18 protein | PMID:17321000 PMID:17850464 PMID:21677146 PMID:22147977 PMID:25448682 PMID:25890327 PMID:26582142 PMID:35099110 | Il18 | increases secretion | ISO | IL18 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased secretion of IL18 protein | PMID:15289356 PMID:20421217 PMID:27377765 PMID:29567563 PMID:33930521 PMID:34791735 | Il18 | multiple interactions | ISO | IL18 (Homo sapiens) | 6480464 | CTD | 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; [Acetaminophen co-treated with Lipopolysaccharides] affects the expression of IL18 mRNA; [Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; [usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA]; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL18 protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL18 protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL18 protein]; apigenin-6,8-di-C-glycopyranoside inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; belnacasan inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]; fraxinellone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]; GGTI 298 promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]; IL18 protein promotes the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; IL18 protein promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Lipopolysaccharides inhibits the reaction [swietenine inhibits the reaction [Glucose results in increased expression of IL18 protein]]; Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL18 protein]; Lipopolysaccharides promotes the reaction [Glucose results in increased expression of IL18 protein]; Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]; Lipopolysaccharides promotes the reaction [Propofol results in increased expression of IL18 mRNA]; Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]; Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein; monophosphoryl lipid A inhibits the reaction [USP18 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; NLRP3 protein affects the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; NLRP3 protein inhibits the reaction [PRKAA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; NLRP3 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; PRKAA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; Quercetin inhibits the reaction [NLRP3 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]; Resveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of IL18 protein]; Rotenone promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; SIRT1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; ubiquinone-O inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 protein]; USP18 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein] | PMID:17399992 PMID:21147091 PMID:22777745 PMID:24149798 PMID:25448682 PMID:26431797 PMID:27377765 PMID:28964808 PMID:29567563 PMID:30205151 PMID:31059760 PMID:31993881 PMID:33579316 PMID:33851234 PMID:33930521 PMID:34791735 PMID:35331853 PMID:35953652 PMID:36055550 PMID:36066211 PMID:36847822 | Il18 | multiple interactions | ISO | Il18 (Mus musculus) | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; [Fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]]; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein; [Lipopolysaccharides co-treated with Indirubin E804] results in decreased expression of IL18 mRNA; [Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; [triptolide co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; [triptolide co-treated with Lipopolysaccharides] results in increased secretion of IL18 protein; DCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein]; DCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; Estrogens inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; fraxinellone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]; Hirudins inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein; lycium barbarum polysaccharide inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; lycium barbarum polysaccharide inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]; methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; NLRP3 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]; NLRP3 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL18 protein]; Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA] | PMID:15933225 PMID:17850464 PMID:21677146 PMID:23107598 PMID:25448682 PMID:26431797 PMID:26582142 PMID:34212273 PMID:35099110 PMID:36328986 | | ||||||||||||||||||||||
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