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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il18multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of IL18 protein]PMID:22426011 PMID:23647015
Il18multiple interactionsISOIL18 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; Quercetin inhibits the reaction [NLRP3 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]PMID:34791735
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