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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases expressionEXP 6480464CTDCyclophosphamide results in decreased expression of IL10 proteinPMID:25451569
Il10increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of IL10 proteinPMID:11948286 PMID:18848347 PMID:37263553
Il10multiple interactionsEXP 6480464CTDAnthocyanins inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL10 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]PMID:25451569 PMID:37263553
Il10decreases expressionISOIl10 (Mus musculus)6480464CTDCyclophosphamide results in decreased expression of IL10 mRNAPMID:11014644
Il10increases expressionISOIl10 (Mus musculus)6480464CTDCyclophosphamide results in increased expression of IL10 mRNAPMID:21068404
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTD[Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL10 proteinPMID:31651976
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