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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10affects response to substanceISOIL10 (Homo sapiens)6480464CTDIL10 gene SNP affects the susceptibility to Arsenic; IL10 promoter polymorphism affects the susceptibility to ArsenicPMID:21357384 PMID:25759212
Il10decreases expressionISOIL10 (Homo sapiens)6480464CTDArsenic results in decreased expression of IL10 gene; Arsenic results in decreased expression of IL10 mRNAPMID:27838757 PMID:35363433
Il10increases expressionISOIl10 (Mus musculus)6480464CTDArsenic results in increased expression of IL10 proteinPMID:27289040
Il10increases expressionISOIL10 (Homo sapiens)6480464CTDArsenic results in increased expression of IL10 proteinPMID:35363433
Il10increases methylationISOIL10 (Homo sapiens)6480464CTDArsenic results in increased methylation of IL10 genePMID:27838757
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of IL10 mRNAPMID:30889423
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTD[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 proteinPMID:23962110
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