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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf2r
Name: insulin-like growth factor 2 receptor
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf2rdecreases expressionISOIGF2R (Homo sapiens)6480464CTDFolic Acid results in decreased expression of IGF2R mRNAPMID:21867686
Igf2rincreases methylationISOIgf2r (Mus musculus)6480464CTDFolic Acid results in increased methylation of IGF2R mRNAPMID:22959928
Igf2rmultiple interactionsISOIgf2r (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of IGF2R mRNA; [Folic Acid co-treated with sodium arsenite] results in increased methylation of IGF2R mRNAPMID:22206623 PMID:22959928
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