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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor 1 receptor
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rincreases expressionEXP 6480464CTDGenistein results in increased expression of IGF1R mRNA; Genistein results in increased expression of IGF1R proteinPMID:16443925 PMID:17049845
Igf1rmultiple interactionsEXP 6480464CTD[Genistein co-treated with Methoxychlor] results in increased expression of IGF1R mRNA; [Genistein co-treated with Methoxychlor] results in increased expression of IGF1R protein; [Methoxychlor co-treated with Genistein] results in increased expression of IGF1R proteinPMID:11896288 PMID:16443925
Igf1rdecreases expressionISOIGF1R (Homo sapiens)6480464CTDGenistein results in decreased expression of IGF1R mRNAPMID:16865672
Igf1rincreases expressionISOIgf1r (Mus musculus)6480464CTDGenistein results in increased expression of IGF1R mRNAPMID:32186404
Igf1rmultiple interactionsISOIgf1r (Mus musculus)6480464CTDESR1 protein promotes the reaction [Genistein results in increased phosphorylation of and results in increased activity of IGF1R protein]; Genistein results in increased phosphorylation of and results in increased activity of IGF1R proteinPMID:10965916
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTDGenistein inhibits the reaction [bisphenol A results in increased expression of IGF1R mRNA]; Genistein inhibits the reaction [Estradiol results in increased expression of IGF1R mRNA]PMID:23933164
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