Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1increases secretionEXP 6480464CTDDihydrotestosterone results in increased secretion of IGF1 proteinPMID:25667201
Igf1multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [Dihydrotestosterone results in increased secretion of IGF1 protein]PMID:25667201
Igf1decreases expressionISOIgf1 (Mus musculus)6480464CTDDihydrotestosterone results in decreased expression of IGF1 mRNAPMID:17023530 PMID:36822333
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDDihydrotestosterone results in increased expression of IGF1 mRNAPMID:16368782 PMID:29581250
Igf1increases secretionISOIGF1 (Homo sapiens)6480464CTDDihydrotestosterone results in increased secretion of IGF1 proteinPMID:16368782
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTDbicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]; Flutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]PMID:16368782
Go Back to source page   Continue to Ontology report