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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:5296
Term: gemfibrozil
Definition: An aromatic ether that has formula C15H22O3.
Chemical ID: MESH:D015248
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDGemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased activity of PPARA protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased activity of CEBPB protein]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]PMID:12244038
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