GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ifng | decreases expression | EXP | | 6480464 | CTD | sodium arsenite results in decreased expression of IFNG protein | PMID:19145326 | Ifng | multiple interactions | EXP | | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IFNG protein; mecobalamin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IFNG protein] | PMID:33739591 | Ifng | affects expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | sodium arsenite affects the expression of IFNG mRNA | PMID:28843991 PMID:34272803 | Ifng | decreases expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of IFNG mRNA; sodium arsenite results in decreased expression of IFNG protein | PMID:34166680 PMID:36435854 | Ifng | decreases response to substance | ISO | Ifng (Mus musculus) | 6480464 | CTD | IFNG protein results in decreased susceptibility to sodium arsenite | PMID:17003472 | Ifng | decreases secretion | ISO | Ifng (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased secretion of IFNG protein | PMID:24218229 | Ifng | increases expression | ISO | IFNG (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of IFNG mRNA | PMID:26535918 | Ifng | increases expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of IFNG mRNA; sodium arsenite results in increased expression of IFNG protein | PMID:17003472 PMID:26631322 PMID:32760496 PMID:35364107 PMID:37682722 | Ifng | multiple interactions | ISO | IFNG (Homo sapiens) | 6480464 | CTD | sodium arsenite inhibits the reaction [IFNG protein results in increased activity of JAK1 protein]; sodium arsenite inhibits the reaction [IFNG protein results in increased activity of JAK2 protein]; sodium arsenite inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA]; sodium arsenite inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA] | PMID:15116095 PMID:30021835 | Ifng | multiple interactions | ISO | Ifng (Mus musculus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of IFNG mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IFNG mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IFNG protein; Curcumin inhibits the reaction [sodium arsenite affects the expression of IFNG mRNA]; IFNG protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein]; IFNG protein inhibits the reaction [sodium arsenite results in increased expression of ATF3 protein]; IFNG protein inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; IFNG protein promotes the reaction [sodium arsenite results in increased expression of ABCC1 protein]; Immune Checkpoint Inhibitors inhibits the reaction [sodium arsenite results in decreased expression of IFNG protein]; Selenomethionine inhibits the reaction [sodium arsenite results in decreased secretion of IFNG protein]; sodium arsenite inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; sodium arsenite inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; sodium arsenite results in decreased susceptibility to [TNF protein co-treated with IFNG protein] | PMID:17003472 PMID:24218229 PMID:30889423 PMID:33148380 PMID:33739591 PMID:34166680 PMID:34272803 PMID:8903404 | |
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