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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:28148
Term: sodium stibogluconate
Definition: A D-gluconate adduct of indefinite composition containing between 30 and 34% of antimony(V), calculated with reference to dried and methanol-free substance. It is used as a treatment for leishmaniasis.
Chemical ID: MESH:D000967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngaffects response to substanceISOIfng (Mus musculus)6480464CTDIFNG protein affects the susceptibility to Antimony Sodium GluconatePMID:10603400
Ifngdecreases expressionISOIFNG (Homo sapiens)6480464CTDAntimony Sodium Gluconate results in decreased expression of IFNG mRNAPMID:20102417 PMID:9498473
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG proteinPMID:17911647
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD[IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL10 mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL4 mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of IL12B mRNA; [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of NOS2 mRNA; IFNG protein affects the reaction [IL10RA protein affects the susceptibility to Antimony Sodium Gluconate]PMID:12870129 PMID:9234779
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