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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:17967
Term: urethane
Definition: A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.
Chemical ID: MESH:D014520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionISOIfng (Mus musculus)6480464CTDUrethane results in decreased expression of IFNG mRNAPMID:12810352
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDUrethane results in increased expression of and results in increased secretion of IFNG proteinPMID:18082304
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTD[Urethane co-treated with IFNG protein] results in increased expression of PDGFA mRNA; [Urethane co-treated with IFNG protein] results in increased expression of PRL mRNA; [Urethane co-treated with IFNG protein] results in increased expression of PTGER2 mRNA; [Urethane co-treated with IFNG protein] results in increased expression of WEE1 mRNA; Freund's Adjuvant inhibits the reaction [Urethane results in decreased expression of IFNG mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of BCL2 mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of CSF2 mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of EDNRB mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of FOS mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of IFNG mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of IL10 mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of IL4 mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of JUN mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of PDGFB mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of PRKCA mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of TGFB1 mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of TGFB2 mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of TGFB3 mRNA]; IFNG protein inhibits the reaction [Urethane results in decreased expression of TRP53 mRNA]; IFNG protein promotes the reaction [Urethane results in increased expression of EGFR mRNA]; IFNG protein promotes the reaction [Urethane results in increased expression of IGF1 mRNA]; IFNG protein promotes the reaction [Urethane results in increased expression of IGF2 mRNA]; IFNG protein promotes the reaction [Urethane results in increased expression of IL2 mRNA]; IFNG protein promotes the reaction [Urethane results in increased expression of PTGER1 mRNA]PMID:11091364 PMID:12810352
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